Abstract: We extracted and obtained the spatial distribution of the coastline in the northeast Zhanjiang Coast by using human-computer interaction technique based on 6 scenes of LandSat TM/OLI images in recent 30 years. The spatial-temporal variations of the coastline and its driving factors are further investigated by combining the End Point Rate (EPR)，the Linear Regression Rate (LRR), and the Coastline Type Structure analysis. The total length of the coastline increased during the last 30 years while natural coastline decreased. The coastline categories changed frequently and their utilization types became complicated due to human activities. The results show that the average LRR and EPR of the continental coastline were 4.18 m/a and 4.12 m/a, respectively，with the highest LRR 94.26 m/a. And the ones of the island coastline were 2.24 m/a and 3.79 m/a, respectively, with the highest LRR 66.44 m/a. Furthermore, coastline with the largest changing rate were mainly affected by human activities, which was proved to be the leading factor for the coastline change in the northeast Zhanjiang during the last 30 years.